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Showing posts from February, 2018

Haloperidol does not prevent delirium or improve survival rates in ICU patients

Prophylactic use of the drug haloperidol does not help to prevent delirium in intensive care patients or improve their chances of survival. Therefore, there is no reason anymore to administer the drug as a preventive measure to reduce the burden of delirium. This was revealed following a three-year, large-scale study among 1,800 patients in 20 Dutch ICUs.

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Minimising risks of transplants

A bone marrow transplant is often the only therapy available to save leukaemia patients, but the risk of complications is high. Nearly half of all patients experience an unwanted reaction of their immune system, which often attacks their skin and liver and in up to 50 percent of cases the intestines. Researchers have succeeded in deciphering what causes this in some instances life-threatening inflammation of the intestines.

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Depression linked to reduced arginine levels

People suffering from major depressive disorder, MDD, have reduced arginine levels, a new study shows.

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Unexpected discovery about essential enzyme

The enzyme that produces DNA building blocks plays an important role when cells divide. In a new study, researchers have discovered for the first time that the so-called master switch of the enzyme can change locations -- while still performing the same task.

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An improved anti-addiction medication

Drug addiction continues to plague vast numbers of people across the world, destroying and ending lives, while attempts to develop more effective pharmaceutical addiction treatments continue. Scientists now report the development of a potent new medicine to fight addiction, which might also be an effective treatment for epilepsy and other conditions.

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Wine polyphenols could fend off bacteria that cause cavities and gum disease

Sipping wine is good for your colon and heart, possibly because of the beverage's abundant and structurally diverse polyphenols. Now researchers report that wine polyphenols might also be good for your oral health.

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Getting sleepy? Fruit flies constantly tune into environmental temperature to time sleep

Humans and fruit flies may have not shared a common ancestor for hundreds of millions of years, but the neurons that govern our circadian clocks are strikingly similar.

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New video by Global Cycling Network on YouTube

How To Improve Your Confidence After A Crash | GCN's Cycling Tips
Have you had a spill that has knocked your confidence? Here's how to get back on your bike and happy to ride again. Subscribe to GCN: http://gcn.eu/SubscribeToGCN Register your interest in the GCN Club: http://gcn.eu/yS Get exclusive GCN gear in the GCN shop! http://gcn.eu/yT Here's our top tips for getting you back on your bike and your confidence back after a spill. 1. Take time to recover 2. Understand your fears 3. Practise your fears 4. Share your location Let us know how you've got over an accident in the comments below. If you'd like to contribute captions and video info in your language, here's the link 👍 http://gcn.eu/yR Watch more on GCN... Think Yourself Faster 📹 http://gcn.eu/ThinkYourselfFaster Music: Awoken - Purple Dive Battle Cry 1 - Gustavsson & Sandberg Photos: © Bettiniphoto / http://ift.tt/1lSk8Ay & ©Tim De Waele / http://www.tdwsport.com About GCN: The Global Cycling…

Ancient-DNA researchers surpass the 1,000-genome milestone

In the last eight years, the field of ancient DNA research has expanded from just one ancient human genome to more than 1,300. The latest 625 of those genomes debut Feb. 21 in Nature, including the largest study of ancient DNA to date.

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Struggling to Achieve My Potential in Life

I’ve been told several times in my life that I have lots of potential but recently I turned 45 last month. I want to do something great in my life but don’t know which direction to go into. also, to achieve one’s potential, doesn’t it help greatly to have people behind you and support your efforts? I don’t have the support system that I greatly desire. when I was young I did not know what potential even meant but now thanks to the internet I understand it better. I’ve done lots of research on it online and have read lots of articles and such. still, I can’t understand why someone as smart as me can’t find great success. is there any hope for me? how can I get rid of the nagging feeling that I haven’t done enough yet?A: You’ve answered your own question. The first think is to find a tribe, a support network of people you can give support to-and receive support from. This is the foundation upon which achievement is based. If you haven’t read the book Flourish by Martin Seligman, you sho…

Novel mechanism behind schizophrenia uncovered

Researchers have uncovered a novel mechanism in which a protein--neuregulin 3--controls how key neurotransmitters are released in the brain during schizophrenia. The protein is elevated in people with schizophrenia and other severe mental illnesses, but the study is the first to investigate how it causes such severe mental illness.

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Cross-bred flies reveal new clues about how proteins are regulated

The investigators used a technique called bottom-up proteomics (sometimes called shotgun proteomics) to reveal which proteins of each species were present in the hybrid flies.

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New video by Global Mountain Bike Network on YouTube

How To Ride Hip Jumps On Your Mountain Bike | MTB Skills
Hip jumps are insanely fun to hit on your mountain bike! Whether it's a long low step down or a tall booter that sends you sky high! We've all got to start somewhere, so here are the basics of getting that hip jump dialled so that you can exaggerate the technique to hit bigger and bigger jumps! Subscribe to GMBN: http://ift.tt/1HnIPRp Get exclusive GMBN gear in the GMBN store! http://gmbn.eu/GG As always, start small with these skills and work them up to larger jumps! As a rule, if you're comfortable jumping the distance in question as a tabletop jump, you can jump that size hip! After all, you're taking off at the same speed and trajectory to begin with! Have fun! If you'd like to contribute captions and video info in your language, here's the link 👍 [http://gmbn.eu/GF 🎵A nifty piece of work - Andres Bothen - Epidemic Sounds 🎵 Watch more on GMBN... Check out Blake's day in the life at DarkFEST http…

New interaction mechanism of proteins discovered

Researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity complex due to their opposite net charge. Proteins usually bind one another as a result of perfectly matching shapes in their three-dimensional structures.

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Social media as good a barometer of public health attitudes as traditional phone polling

Social media data can be used as an additional source of information to gauge public opinion about health issues alongside traditional data sources like phone-based polling, according to new research.

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MRI stroke data set released

Researchers have compiled, archived and shared one of the largest open-source data sets of brain scans from stroke patients. The data set, known as ATLAS, is available for download. Researchers globally are using the scans to develop and test algorithms that can automatically process MRI images from stroke patients. In the long run, scientists hope to identify biological markers that forecast which patients will respond to various rehabilitation therapies and personalize treatment plans.

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Housing problems found to be common at safety-net community health centers

A new study finds that more than 40 percent of patients treated at community health centers in the United States have a history of housing problems.

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Medicine alone does not completely suppress testosterone levels among transgender women, study finds

A new study finds that the majority of transgender women who follow the usual approach prescribed in the United States are unable to reliably lower their testosterone levels into the typical female physiologic range with medicine alone.

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New video by Global Cycling Network on YouTube

Abu Dhabi Tour 2018 | Stage 1 Race Report
The final leg in the triad of Middle Eastern races concludes this week with Abu Dhabi Tour. Focusing on today’s opening stage though, and it’s one for the sprinters, at least on paper. Subscribe to GCN: http://gcn.eu/SubscribeToGCN Register your interest in the GCN Club: http://gcn.eu/yW Get exclusive GCN gear in the GCN shop! http://gcn.eu/yU Mark Cavendish won the stage into Madinat Zayed last year, but the race hadn’t even got out of the neutral zone when a crash took right behind the commissaire’s car took out Dimension Data’s star sprinter. Signs of concussion meant it was impossible for Cavendish to continue, we wish him a very speedy recovery. The final sprint was a tale of two sides, with Quick-Step spreading to the left hand barrier. Meanwhile, Alexander Kristoff was biding his time on the opposite side of the road, and while Viviani and Ewan faded in the headwind, the European champion dashed for the line with a strong, well timed kic…

Countries investing in well-being allocate resources to child and adolescent psychiatry

A new research report shows that a high ranking in the Human Development Index is connected with the availability of mental health services. In a comparison between 17 European and Asian countries, Norway, Switzerland and Finland had the highest ratio of child and adolescent psychiatrists.

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Marijuana: Good or bad?

More and more, marijuana is being legalized for medicinal or recreational purposes, but what are the health benefits and risks of the drug? We investigate.

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Securing a child's future needs to start during parents' teen years

A child's growth and development is affected by the health and lifestyles of their parents before pregnancy -- even going back to adolescence -- according to a new paper.

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Creative couples' intervention significantly helps people with Alzheimer's communicate

For couples with decades of shared memories, a partner's decline in the ability to communicate because of dementia is frightening and frustrating. Communication strategies they've used before simply don't work anymore. By getting creative, an in-home intervention to support couples affected by dementia is showing that 'practice does make perfect,' both for the caregiver and the care receiver or person with dementia, and can improve their communication behaviors in just 10 weeks.

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Zika virus could help combat brain cancer

Researchers show that infection by Zika caused death of cells from glioblastoma, the most common and aggressive kind of malignant brain tumor in adults. Scientists foresee the use of genetic engineering to neutralize Zika virus' infectious whilst preserving the viral particles which induce the death of tumoral cells.

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Bacteria produce more substances than hitherto assumed

The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment. They might also include molecules that are of interest as potential pharmaceutical agents. A research team analysed a broad spectrum of the bacterium's metabolic products under various culture conditions.

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Film Memento helped uncover how the brain remembers and interprets events from clues

In the Christopher Nolan film Memento (2000) the protagonist suffers from long-term memory loss and is unable to retain new memories for no longer than a few minutes. The events unfold in reversed chronological order. The results deepen our understanding of how the brain functions, how narratives work in film, and memory mechanisms impaired by conditions such as Alzheimer's disease.

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How one enzyme could stop the spread of cancer

A study reveals that activation of the enzyme RIPK1 can trigger cell death in cancer cells poised to migrate by causing them to degrade their mitochondria.

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New video by ABC HEALTH on YouTube

Thyroid Disorder and Diabetes | ABC Health
Watch► Thyroid Disorder and Diabetes | ABC Health Hi Friends, Watch #ABCHealth More Videos Subscribe to us : https://goo.gl/elS2MW And Also Follow Us On Facebook: https://goo.gl/EPRq1H Blogger : https://goo.gl/qPZi5Q Google + : https://goo.gl/EvYekq Playlist : https://goo.gl/u4HjXn hypothyroidism and diabetes mellitus diabetes and thyroid disease a likely combination hypothyroidism and diabetes type 1 can thyroid problems affect blood sugar levels? thyroid and diabetes diet levothyroxine diabetes can hypothyroidism cause diabetes thyroid and blood sugar fluctuations "thyroid disease and infertility" "thyroid disease goiter" "link between hypothyroidism and diabetes" "hypothyroidism and insulin resistance" "subclinical thyroid disease" "hypothyroidism type 2 symptoms" "thyroid disease and depression" "thyroid diabetes" "thyroid replacement therapy" "h…

Brain size of human ancestors evolved gradually over 3 million years

Modern humans have brains that are more than three times larger than our closest living relatives, chimpanzees and bonobos. Scientists don't agree on when and how this dramatic increase took place, but new analysis of 94 hominin fossils shows that average brain size increased gradually and consistently over the past three million years.

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How can I lower my insulin levels?

In this article, we look at nine ways to lower high insulin levels. This can be achieved through diet, lifestyle changes, supplements, and medication.

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Bolstering Self-Concept in Young Mental Health Patients May Aid in Treatment

New research suggests an important part of treatment for young mental health patients — especially those in a hospital setting — is improving how they perceive themselves, according to a study from the University of Waterloo.Researchers found that youth with psychiatric disorders receiving inpatient services reported lower self-concept — particularly global self-worth — compared to those receiving outpatient services.“This was the first study that examined youth with psychiatric disorders by comparing what type of service they were receiving and whether that was associated with self-concept,” said Dr. Mark Ferro, an assistant professor in the Faculty of Applied Health Sciences at Waterloo.“We know that global self-worth is lower in the inpatient group and we know from other research that lower self-concept is a precursor to other more serious mental health problems.”The study, which appears in the Journal of the Canadian Academy of Child and Adolescent Psychiatry, examined 47 youth ag…

Both Older and Younger Siblings Impact Each Other’s Empathy Levels

A new multi-university study finds that both older and younger siblings, even toddlers, can have a significant influence on the other’s capacity for empathy.The study, published in the journal Child Development, was conducted by researchers at the University of Calgary, Universite Laval in Quebec City, Tel Aviv University, and the University of Toronto.Like parents, older brothers and sisters act as role models and teachers, helping their younger siblings learn about the world. Children whose older siblings are kind, warm, and supportive, for example, tend to be more empathetic than children whose siblings lack these traits.In the new longitudinal study, researchers wanted to know whether very young children can also contribute to their older sibling’s capacity for empathy in early childhood, when empathetic tendencies begin to develop.“Our findings emphasize the importance of considering how all members of the family, not just parents and older siblings, contribute to children’s deve…

I Doubt Myself and Change My Personality Daily

From a 14 year old girl in the U.S.: All my life i’ve tried to be different people. any sort of charscter or musician or anything that i’ve gotten attatched to, i try to become. it’s a HUGE problem and seems to even affect my thought patterns. there was a character that i tried to become who had anorexia and, though i’ve been struggling with body image issues since i was 8, it seemed to act up and get remarkably bad. this seems to start to affect my reactions to things and the way i think.it’s concerning me, and i just want to know what mental health issues this could be related to. i’ve sort of lost myself along the way, and it’s caused me a lot of distress. sometimes i’m just like who i want to be, sometimes i can’t seem to conform to how a certain person acts, and sometimes i lose all hope and realize that i’m really no one at all. i’m like a chameleon and it causes me to doubt myself and change my personality daily. i feel like there may be something seriously wrong with me, to be…

Social Media Does Not Significantly Harm Adolescent Academic Performance

Despite widespread concern among parents and educators, using social media may not adversely impact teens’ academic performance, according to a new study in Educational Psychology Review.“Concerns regarding the allegedly disastrous consequences of social networking sites on school performance are unfounded,” said Professor Markus Appel, a psychologist who holds the Chair of Media Communication at Julius-Maximilians-Universität Würzburg (JMU) in Bavaria, Germany.Appel, doctoral student Caroline Marker, and Dr. Timo Gnambs from the University of Bamberg investigated how the social media use of adolescents correlates with their school grades.“There are several contradictory single studies on this subject and this has made it difficult previously to properly assess all results,” Marker said. Some studies report negative impacts of Snapchat & Co., others describe a positive influence or do not find any relationship at all.The researchers conducted meta-analyses from relevant databases …

The Good News and Bad News: You’re Out of A Job

It’s said that, “When you hit rock bottom, there’s nowhere to go but up.” That can prove especially true in business, where bottoming out after job loss can be necessary before finding the radical solution that will lead to a new work identity, according to new research from the University of Notre Dame.“When you hit rock bottom, there’s nowhere to go but up.” This can prove especially true in business, where bottoming out as a result of job loss can be necessary before finding the radical solution that will lead to a new work identity, said University of Notre Dame researcher Dean Shepherd, Ph.D., lead author of a new study on job loss.Shepherd, the Siegfried Professor of Entrepreneurship in Notre Dame’s Mendoza College of Business, and Trenton Williams of Indiana University performed the study.“On the way down, we frantically do all sorts of things to try and repair the situation, and suffer as they fail,” Shepherd says.“Bottoming out frees us from the misconception that the problem…

Tracking traffic in the divided world of a nerve cell

Axonal and dendritic proteins embedded in the membrane at either end -- called transmembrane proteins -- are built in the same cellular factory and travel on the same cellular highway. But for the cell to function property, they must be delivered to the correct domain. So how does the cell regulate that voyage?

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How people cope with difficult life events fuels development of wisdom, study finds

How a person responds to a difficult life event such as a death or divorce helps shape the development of their wisdom over time, a new study suggests.

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Higher risk of dementia for adults with congenital heart disease, study shows

A new study is believed to be the first to show a higher risk of dementia in adults who were born with heart disease. The study of more than 10,000 adult with congenital heart disease (CHD) in Denmark discovered a particularly increased risk for early dementia in middle-age adults.

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Antibodies protect nerve-muscle connections in a mouse model of Lou Gehrig's disease

A new study identifies a novel treatment strategy that preserved neuromuscular synapses in a mouse model of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

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Brain immune system is key to recovery from motor neuron degeneration

Researchers engineered mice in which the damage caused by a mutant human TDP-43 protein could be reversed by one type of brain immune cell. TDP-43 is a protein that misfolds and accumulates in the motor areas of the brains of ALS patients. They found that microglia, the first and primary immune response cells in the brain and spinal cord, are essential for dealing with TDP-43-associated neuron death.

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Bacteria-eaters to prevent food poisoning?

Bacteria-killing viruses could be employed not just in health care, but also in the food industry, a new study shows. The researchers have been investigating the possibility of utilizing phages in eradicating food-borne pathogens and preventing food poisoning.

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Scientists find new antimalarial drug targets

Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets. The team are already working with pharmaceutical companies to use this knowledge to develop new antimalarial drugs -- a critical step in the battle against drug-resistant malaria.

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More awareness, research needed on abuse risk of non-opioid painkiller

Gabapentin, a nerve pain medication and anticonvulsant, increasingly is being misused, necessitating prescribers to understand its abuse potential and risk profile, according to a new study.

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'Icebreaker' protein opens genome for T-cell development, researchers find

Researchers describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in developing new therapies using epigenetic drugs to alter T-cell fate in cancer, autoimmune disorders, and infectious diseases.

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'Click chemistry' reactions may boost cancer-fighting drug potency

Researchers have developed a quick and easy way to simultaneously modify dozens of drugs or molecules to improve their disease-fighting properties.

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How health authorities fight the spread of infectious diseases

Public outreach campaigns can prevent the spread of devastating yet treatable diseases such as tuberculosis, malaria and gonorrhea. But ensuring these campaigns effectively reach undiagnosed patients, who may unknowingly spread the disease to others, is a major challenge for cash-strapped public health agencies. Now, a team of researchers has created an algorithm that can help policymakers reduce the overall spread of disease.

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Stroke drug demonstrates safety in clinical trial

A preliminary Phase 2 clinical trial has demonstrated that patients with acute ischemic stroke, the most common type of stroke, can safely tolerate high doses of 3K3A-APC, a promising anti-stroke drug.

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Being female is not a protective factor against heart disease in type 1 diabetes

Constrictions of the coronary blood vessels is a possible consequence of type 1 diabetes, and one that can eventually lead to myocardial infarction or heart failure. Generally speaking, women are afflicted by coronary artery disease later than men, but if a woman has type 2 diabetes, the advantage is negated. A new report now shows that this also sometimes applies to type 1 diabetes.

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Data detectives shift suspicions in Alzheimer's from usual suspect to inside villain

The pursuit of the usual suspect in Alzheimer's research may be distracting from a more direct culprit in the disease, according to a study that analyzed data from 51 published experiments. P-tau looked a good bit more culpable than amyloid-beta plaque.

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Alcohol use disorder is a 'major risk factor' for dementia

In a large-scale study, links between alcohol use disorder and dementia are fleshed out. The relationship is stronger than previously thought.

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High blood pressure limits protection to vital organs and tissues in low-oxygen conditions

New research sheds light on the effects of high blood pressure by considering the way the body responds to a lack of oxygen.

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MicroRNA could help treat cancer and asthma

A microRNA that regulates inflammation shows promise as a treatment for inflammatory diseases such as asthma and cancer, according to new research.

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Brain liquefaction after stroke is toxic to surviving brain

Researchers suggest liquefied brain fluid may be one cause of dementia after stroke.

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Preventing the misdiagnosis of cellulitis

A new study finds early dermatology consultation for presumptive cellulitis can improve patient outcomes, reduce costs and reduce hospitalization.

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Largest study of its kind finds alcohol use biggest risk factor for dementia

Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study of over one million adults diagnosed with dementia in France.

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Resolvin D-1 limits kidney damage after heart attacks

A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If the inflammation lingers, it can lead heart failure. The inflammation can also claim another victim -- the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model. This suggests potential application to the clinical setting.

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Protein levels in spinal fluid correlate to posture and gait difficulty in Parkinson's

Levels of a protein found in the brain called alpha-synuclein are significantly lower than normal in cerebrospinal fluid collected in Parkinson's disease patients suffering from postural instability and gait difficulty, a study has found.

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